Medicine – Living Well While Surviving Cancer

Two Research-Based Medication Findings

Studies on kidney disease and A-fib.

As we know, particular medications may or may not be for us. Even if they are fine for others. Let’s consider two examples.

Heartburn and Our Kidneys

Marget Robinson of the University of Buffalo reports that:

“Common medications for heartburn, acid reflux, and ulcers are linked to increased risks of kidney failure and chronic kidney disease, according to a new study. Use of proton pump inhibitors (PPI), a group of drugs that reduce the production of stomach acid, may increase risk as much as 20 percent — and also come with a four times greater risk of kidney failure, researchers say. People at least 65 years old have the highest risk.”

“The research, which appears in Pharmacotherapy, is one of the first large, long-term studies to examine the effects of PPIs on kidney function. Researchers examined health data of more than 190,000 patients over a 15-year period. ‘This study adds to a growing list of concerning side effects and adverse outcomes associated with PPIs,’ says David Jacobs, lead investigator and assistant professor of pharmacy practice in the University at Buffalo School of Pharmacy and Pharmaceutical Sciences. ‘Given the increasing global use of PPIs, the relationship between PPIs and renal disease could pose a substantial disease and financial burden to the health care system and public health.'”

Click the image to read more.

A-Fib and Aspirin

Sarah Avery of Duke University reports that:

“The drugs apixaban and clopidogrel — without aspirin — comprise the safest treatment regimen for certain patients with atrial fibrillation (A-fib), according to new research. The finding — which applies specifically to patients with A-fib who have had a heart attack and/or are undergoing percutaneous coronary intervention—should reassure clinicians and patients that dropping aspirin results in no significant increase in ischemic events such as heart attacks, strokes, and blood clots.”

“The researchers presented data from the large study, known as AUGUSTUS, at the American College of Cardiology annual meeting. ‘We have a lot of studies on antithrombotic drugs in patients with coronary artery disease and similarly in patients with A-fib, but few studies in patients with both conditions,’ says cardiologist Renato D. Lopes, principal investigator for the trial and a member of the Duke University Clinical Research Institute. ‘The reality is that doctors and patients have a challenge in treating these patients without causing bleeding. The results of this trial give us an opportunity to better understand how to best treat them.'”

Now, look at a brief video on the study.

Fight Medicare Fraud and Protect Your Identity

Great Medicare resources!!

Medicare offers numerous tips through its Web site. And it offers good advice to help you fight Medicare fraud and protect your identity.

In a recent E-mail, Medicare offered three specific tips:

1. Protect your identity. “Identity theft happens when someone uses your personal information without your consent to commit fraud or other crimes. Guard your Medicare Number and card, and keep your Social Security Number safe.”
2. Help fight Medicare fraud. “Use your MyMedicare account to stay on top of your claims. If you find errors or fraud, report it to us. Don’t have a MyMedicare account yet? Sign up for free at MyMedicare.gov today.”
3. Know your rights. “You have certain rights and protections designed to make sure you get the health care services the law says you can get.”

Click the Medicare logo to learn more about its resources.

Doctors’ Roles and Responsibilities

See what doctors’ jobs encompass. With video.

Earlier this month, I gave a presentation to about 65 residents and other doctors at the Queens Hospital Center in Jamaica, New York. The topic? “Roles in Patient-Doctor Relationships: Seeing Both Sides”

Over the next several posts, various aspects of that talk will be highlighted:

- - Doctors’ Roles and Responsibilities (including doctor morale)
  - Patients’ Roles and Responsibilities (and what doctors wish patients knew)
  - Stages of Patient Frustration and Satisfaction
  - Doctor Actions Improving Patient Relationships
  - Patient Actions Improving Doctor Relationships
  - We’re Not There Yet on Doctor-Patient Relationships

Doctors typically have the roles and responsibilities highlighted in this image. How do YOU rate each of your doctors across these roles and responsibilities?

As patients, it is also vital for us to understand the factors that may affect our doctors’ performance. This video shows a few such factors.

Be Careful with OTC Drugs

OTC drugs are not risk-free!

For many people, there is a misconception that over-the-counter (OTC) drugs are always safer than prescription drugs. And that simply is not true.

Consider these observations from AARP:

“If the good news is that over-the-counter pain killers such as acetaminophen, ibuprofen, and naproxen won’t put you at risk for addiction issues like prescription opioids or narcotics can, the less good news is that no pain pill comes without the potential for problems, says Nitin Sekhri, medical director of pain management at Westchester Medical Center in Valhalla, N.Y.”

“Acetaminophen, the active ingredient in Tylenol, is considered the safest option by many, and yet, Sekhri notes, it’s still to blame for about 50 percent of acute liver failures in the U.S. Acetaminophen also is the leading reason behind calls to poison control and to blame for more than 50,000 emergency room visits a year.”

“Often problems arise from people not realizing they’ve taken as much acetaminophen as they have. The over-the-counter painkiller isn’t just in Tylenol: It shows up in remedies meant to fight allergies, colds, flu, coughs, and sleeplessness. It’s also an ingredient in prescription painkillers such as Vicodin and Percocet.”

Click the image to read a lot more.

Cancer Research Institute Conference Video

In June, the Cancer Research Institute held its annual cancer awareness conference. Complete with an excellent video, which is shown below.

As it notes at YouTube:

“Our panel of immunotherapy experts discusses the latest cancer immunotherapy advances featured at the world’s largest oncology conference—the 2018 annual meeting of the American Society of Clinical Oncology (ASCO)—with topics including combination immunotherapy, biomarker development, CAR T cell therapies, and new approaches to immune-based cancer treatment.”

“Panelists include Charles G. Drake, M.D., Ph.D., of New York-Presbyterian/Columbia University Medical Center, and Catherine Diefenbach, M.D., and Jeffrey S. Weber, M.D., of the Perlmutter Cancer Center at NYU Langone Health. Jill O’Donnell-Tormey, Ph.D., of the Cancer Research Institute, moderates.”

“We present this video as part of the Answer to Cancer patient and caregiver education program of the Cancer Research Institute, and feature it as part of our sixth annual global awareness campaign, Cancer Immunotherapy Month, in June.”

New Cancer Drug Approved

Those of us battling with cancer often feel research is not moving fast enough.

Yet, researchers are working quite hard. And billions of dollars are being spent.

Quite recently, the FDA approved a new and VERY expensive cancer drug. As CNN reports:

“Vitrakvi is the first medication developed specifically to target tumors based on gene mutations, not their location in the body.”

AI Aids Drug Operations

We know that technology has had a tremendous on the medical field. And artificial intelligence (AI) is coming on strong. Today, we look at how AI aids drug operations.

As William Soliman, President, Accreditation Council for Medical Affairs, notes:

“Recently, two AI drug design companies, Insilico Medicine and A2A Pharmaceuticals joined forces to bring to market a possible treatment for Duchenne muscular dystrophy (DMD) and other rare orphan diseases. Using AI to more rapidly discover optimal pre-clinical candidates may revolutionize the drug development process in the life sciences.”

“What AI can bring to the table is the ability to rapidly and accurately sort through massive amounts of data. This may very well revolutionize how competitive intelligence, drug discovery and stakeholder engagement take place as we know it. Among many functions that medical affairs is tasked with, an important one is stakeholder engagement with External Experts (EE) (formerly known as KOLs or Key Opinion Leaders). For Medical Science Liaisons (MSLs), who are the primary function engaging external stakeholders, there will likely be several changes.”

Click the image to read a lot more.

AI Aids Drug Operations — Medical Affairs and Artificial Intelligence in the Life Sciences